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Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

Abstract:

BACKGROUND: Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known. METHODS: We treated 428 patients who had active rheumatoid arthritis despite methotrexate therapy with placebo or infliximab, a chimeric monoclonal antibody against TNF-alpha, in intravenous doses of 3 or 10 mg per kilogram of bod...

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Publication status:
Published

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Publisher copy:
10.1056/nejm200011303432202

Authors


Lipsky, PE More by this author
van der Heijde, DM More by this author
St Clair, EW More by this author
Breedveld, FC More by this author
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Journal:
The New England journal of medicine
Volume:
343
Issue:
22
Pages:
1594-1602
Publication date:
2000-11-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:cdbf7087-221d-4de1-815f-fac0406ebc0d
Source identifiers:
224268
Local pid:
pubs:224268

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