- Abstract:
-
BACKGROUND: Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known. METHODS: We treated 428 patients who had active rheumatoid arthritis despite methotrexate therapy with placebo or infliximab, a chimeric monoclonal antibody against TNF-alpha, in intravenous doses of 3 or 10 mg per kilogram of bod...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1056/nejm200011303432202
-
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- Journal:
- The New England journal of medicine
- Volume:
- 343
- Issue:
- 22
- Pages:
- 1594-1602
- Publication date:
- 2000-11-05
- DOI:
- EISSN:
-
1533-4406
- ISSN:
-
0028-4793
- URN:
-
uuid:cdbf7087-221d-4de1-815f-fac0406ebc0d
- Source identifiers:
-
224268
- Local pid:
- pubs:224268
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.
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