Journal article
A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.
- Abstract:
-
Tuberculosis remains a global health problem so that a more effective vaccine than bacillus Calmette-Guérin is urgently needed. Cytomegaloviruses persist lifelong in vivo and induce powerful immune and increasing ("inflationary") responses, making them attractive vaccine vectors. We have used an m1-m16-deleted recombinant murine CMV (MCMV) expressing Mycobacterium tuberculosis Ag 85A to show that infection of mice with this recombinant significantly reduces the mycobacterial load after challe...
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- Publication status:
- Published
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- Publisher copy:
- 10.4049/jimmunol.1302523
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Authors
Bibliographic Details
- Publisher:
- American Association of Immunologists
- Journal:
- Journal of Immunology
- Volume:
- 193
- Issue:
- 5
- Pages:
- 2306-2316
- Publication date:
- 2014-09-01
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
477705
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:477705
- UUID:
-
uuid:cdbab28b-3b9a-4b1f-ae38-a36dfef1f798
- Local pid:
- pubs:477705
- Deposit date:
- 2014-08-17
Terms of use
- Copyright date:
- 2014
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