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Journal article

A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Abstract:

Tuberculosis remains a global health problem so that a more effective vaccine than bacillus Calmette-Guérin is urgently needed. Cytomegaloviruses persist lifelong in vivo and induce powerful immune and increasing ("inflationary") responses, making them attractive vaccine vectors. We have used an m1-m16-deleted recombinant murine CMV (MCMV) expressing Mycobacterium tuberculosis Ag 85A to show that infection of mice with this recombinant significantly reduces the mycobacterial load after challe...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1302523

Authors


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Publisher:
American Association of Immunologists
Journal:
Journal of Immunology
Volume:
193
Issue:
5
Pages:
2306-2316
Publication date:
2014-09-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
477705
Language:
English
Keywords:
Pubs id:
pubs:477705
UUID:
uuid:cdbab28b-3b9a-4b1f-ae38-a36dfef1f798
Local pid:
pubs:477705
Deposit date:
2014-08-17

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