Journal article
Simian adenoviruses as vaccine vectors
- Abstract:
-
Replication incompetent human adenovirus serotype 5 (HAdV-C5) has been extensively used as a delivery vehicle for gene therapy proteins and infectious disease antigens. These vectors infect replicating and nonreplicating cells, have a broad tissue tropism, elicit high immune responses and are easily purified to high titers. However, the utility of HAdV-C5 vectors as potential vaccines is limited due to pre-existing immunity within the human population that significantly reduces the immunogeni...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Future Medicine Publisher's website
- Journal:
- Future Virology Journal website
- Volume:
- 11
- Issue:
- 9
- Pages:
- 649-659
- Publication date:
- 2016-09-01
- Acceptance date:
- 2016-08-19
- DOI:
- EISSN:
-
1746-0808
- ISSN:
-
1746-0794
Item Description
- Keywords:
- Pubs id:
-
pubs:648451
- UUID:
-
uuid:cdb71b7f-e750-405f-943f-1fe17be0d76a
- Local pid:
- pubs:648451
- Deposit date:
- 2016-11-04
Terms of use
- Copyright holder:
- Gilbert, S
- Copyright date:
- 2016
- Notes:
-
This article is distributed under the terms of the Creative
Commons Attribution License 4.0 which permits any use,
distribution, and reproduction in any medium, provided
the original author(s) and the source are credited. To
view a copy of the license, visit http://creativecommons.
org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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