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The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Abstract:

Objective Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the identity of the transported lipids, and thus the pathways through which STARD10 regulates β-cell function, are not understood. The aim of this study was to identify the lipids transported and affecte...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molmet.2020.101015

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Role:
Author
ORCID:
0000-0003-1189-3441
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Name:
Wellcome Trust
Grant:
201325/Z/16/Z
Publisher:
Elsevier
Journal:
Molecular Metabolism More from this journal
Article number:
101015
Publication date:
2020-05-13
Acceptance date:
2020-05-05
DOI:
EISSN:
2212-8778
Language:
English
Keywords:
Pubs id:
1104971
Local pid:
pubs:1104971
Deposit date:
2020-05-14

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