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Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis

Abstract:

Aim: Iloperidone is an atypical antipsychotic drug that is mainly metabolized by CYP2D6, CYP3A4, and cytosolic enzymes. Previous studies show that extensive and poor metabolizers of CYP2D6 exhibit different plasma concentrations of iloperidone and its metabolites. The aim of this study was to develop a parent-metabolite population pharmacokinetic (PPK) model to quantify the effects of CYP2D6*10 allele on the pharmacokinetics of iloperidone and its metabolites in Chinese schizophrenia patie...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/aps.2016.96

Authors


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Name:
Program for Science and Technology Research of Hunan Province
Grant:
2012WK3044
More from this funder
Name:
Health Department Foundation of Hunan Province
Grant:
132013-028
More from this funder
Name:
State Scholarship Fund
Grant:
201308430123
More from this funder
Name:
National Natural Science Foundation of China
Grant:
81301924
More from this funder
Name:
International Science and Technology Cooperation Program of China
Grant:
2014DFA30900
Publisher:
Nature Publishing Group
Journal:
Acta Pharmacologica Sinica More from this journal
Volume:
37
Pages:
1499–1508
Publication date:
2016-09-26
Acceptance date:
2016-06-24
DOI:
EISSN:
1745-7254
ISSN:
1671-4083
Pubs id:
pubs:826938
UUID:
uuid:cdac6a26-3daf-468b-83bc-87a63fcd1a30
Local pid:
pubs:826938
Source identifiers:
826938
Deposit date:
2018-04-17

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