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Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: A double-blind randomized controlled trial

Abstract:

Background--Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. Methods and Results--We performed a 1-year, double-blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years with systolic blood pressure (BP) ≥150 mm Hg or diastolic BP ≥95 mm Hg. In phase 1 (weeks 0-16), patients were randomly assigned to initial...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/JAHA.117.006986

Authors


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Name:
National Institute for Health Research
Grant:
12/5003/01
More from this funder
Name:
British Heart Foundation
Grant:
SP/08/002
Publisher:
American Heart Association, Inc.
Journal:
Journal of the American Heart Association More from this journal
Volume:
6
Issue:
11
Pages:
e006986
Publication date:
2017-11-18
Acceptance date:
2017-09-19
DOI:
ISSN:
2047-9980
Keywords:
Pubs id:
pubs:811417
UUID:
uuid:cda7dcf6-f843-43fb-ade7-2439c7dde31f
Local pid:
pubs:811417
Source identifiers:
811417
Deposit date:
2018-03-13

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