- Abstract:
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Background--Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. Methods and Results--We performed a 1-year, double-blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years with systolic blood pressure (BP) ≥150 mm Hg or diastolic BP ≥95 mm Hg. In phase 1 (weeks 0-16), patients were randomly assigned to initial...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.4mb)
-
- Publisher copy:
- 10.1161/JAHA.117.006986
-
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- Publisher:
- American Heart Association, Inc. Publisher's website
- Journal:
- Journal of the American Heart Association Journal website
- Volume:
- 6
- Issue:
- 11
- Pages:
- e006986
- Publication date:
- 2017-11-18
- Acceptance date:
- 2017-09-19
- DOI:
- ISSN:
-
2047-9980
- Pubs id:
-
pubs:811417
- URN:
-
uri:cda7dcf6-f843-43fb-ade7-2439c7dde31f
- UUID:
-
uuid:cda7dcf6-f843-43fb-ade7-2439c7dde31f
- Local pid:
- pubs:811417
- Paper number:
- 11
- Keywords:
- Copyright holder:
- © 2017 MacDonald, et al.
- Copyright date:
- 2017
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: A double-blind randomized controlled trial
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