Journal article icon

Journal article

Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: A double-blind randomized controlled trial

Abstract:

Background--Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. Methods and Results--We performed a 1-year, double-blind, randomized controlled trial in 605 untreated patients aged 18 to 79 years with systolic blood pressure (BP) ≥150 mm Hg or diastolic BP ≥95 mm Hg. In phase 1 (weeks 0-16), patients were randomly assigned to initial...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1161/JAHA.117.006986

Authors


MacDonald, TM More by this author
Williams, B More by this author
Caulfield, M More by this author
Expand authors...
Publisher:
American Heart Association, Inc. Publisher's website
Journal:
Journal of the American Heart Association Journal website
Volume:
6
Issue:
11
Pages:
e006986
Publication date:
2017-11-18
Acceptance date:
2017-09-19
DOI:
ISSN:
2047-9980
Pubs id:
pubs:811417
URN:
uri:cda7dcf6-f843-43fb-ade7-2439c7dde31f
UUID:
uuid:cda7dcf6-f843-43fb-ade7-2439c7dde31f
Local pid:
pubs:811417
Paper number:
11
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP