Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.

Journal article

The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes (CTL) restricted by HLA alleles with similar or identical binding motifs are known to target epitopes at different frequencies, with different functional avidities and with different apparent clinical outcomes. Such differences may be illuminated by the association of similar HLA alleles with distinctive escape pa...

Expand abstract

Authors: Carlson, J; Listgarten, J; Pfeifer, N; Tan, V; Kadie, C

• Publication status: Published
• Journal: Journal of virology
• Volume: 86
• Issue: 9
• Pages: 5230-5243
• Publication date: 2012-05-01
• DOI: 10.1128/jvi.06728-11
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: HLA Antigens; HIV Infections; Alleles; Mutation; Polymorphism, Genetic; HIV-1; Immune Evasion; Gene Expression; Viral Load; Humans; Epitopes