Journal article icon

Journal article

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.

Abstract:

The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes (CTL) restricted by HLA alleles with similar or identical binding motifs are known to target epitopes at different frequencies, with different functional avidities and with different apparent clinical outcomes. Such differences may be illuminated by the association of similar HLA alleles with distinctive escape pa...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/jvi.06728-11

Authors


Journal:
Journal of virology More from this journal
Volume:
86
Issue:
9
Pages:
5230-5243
Publication date:
2012-05-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:312802
UUID:
uuid:cda6bc39-655e-46e0-9b3c-3be55aa09d37
Local pid:
pubs:312802
Source identifiers:
312802
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP