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Effects of 8 h of isocapnic hypoxia with and without muscarinic blockade on ventilation and heart rate in humans.

Abstract:

This study examined the role of muscarinic parasympathetic mechanisms in generating the progressive increases in ventilation (V(E)) and heart rate previously reported with 8 h exposures to hypoxia. The sensitivities of V(E) (G(p)) and heart rate (G(HR)) to acute variations in hypoxia, and V(E) and heart rate during acute hyperoxia were assessed in 10 subjects before and after two 8 h exposures to isocapnic hypoxia (end-tidal P(O2) = 50 mmHg). The responses were measured during muscarinic bloc...

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Publication status:
Published

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Publisher copy:
10.1113/eph8602174

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Experimental physiology More from this journal
Volume:
86
Issue:
4
Pages:
529-538
Publication date:
2001-07-01
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
Language:
English
Keywords:
Pubs id:
pubs:113324
UUID:
uuid:cda3c049-90e4-4ec7-9b15-a7c1579fef29
Local pid:
pubs:113324
Source identifiers:
113324
Deposit date:
2013-11-17

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