Journal article icon

Journal article

β-Adrenergic receptor stimulation inhibits proarrhythmic alternans in postinfarction border zone cardiomyocytes: a computational analysis

Abstract:

The border zone (BZ) of the viable myocardium adjacent to an infarct undergoes extensive autonomic and electrical remodeling and is prone to repolarization alternans-induced cardiac arrhythmias. BZ remodeling processes may promote or inhibit Ca2+ and/or repolarization alternans and may differentially affect ventricular arrhythmogenesis. Here, we used a detailed computational model of the canine ventricular cardiomyocyte to study the determinants of alternans in the BZ and their regulation by ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1152/ajpheart.00094.2017

Authors


More by this author
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Department:
Oxford, MPLS, Computer Science
Role:
Author
More from this funder
Funding agency for:
Rodriguez, B
More from this funder
Funding agency for:
Rodriguez, B
More from this funder
Funding agency for:
Rodriguez, B
Expand funders...
Publisher:
American Physiological Society Publisher's website
Journal:
American Journal of Physiology - Heart and Circulatory Physiology Journal website
Volume:
313
Issue:
2
Pages:
H338-H353
Publication date:
2017-08-01
Acceptance date:
2017-05-23
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Pubs id:
pubs:697954
URN:
uri:cd9b1005-6dc9-4897-9995-1bee4564caed
UUID:
uuid:cd9b1005-6dc9-4897-9995-1bee4564caed
Local pid:
pubs:697954

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP