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Evidence for continued two-brood replication of Plasmodium falciparum in vivo during quinine treatment.

Abstract:

To investigate the relationship between fever and parasite clearance in falciparum malaria, we studied 54 adults with Plasmodium falciparum infections who were all treated with quinine. The median oral temperature profile showed peaks at 24 h intervals during the first 3 days. Although there was no equivalent pattern evident in the median parasite clearance curve, we hypothesize that small numbers of two distinct parasite broods continued to develop in antiphase through schizogony despite qui...

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Publication status:
Published

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Authors


Supanaranond, W More by this author
Pukrittayakamee, S More by this author
Silamut, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
Acta tropica
Volume:
89
Issue:
1
Pages:
41-45
Publication date:
2003-12-05
DOI:
EISSN:
1873-6254
ISSN:
0001-706X
URN:
uuid:cd98aa9a-fb7c-4d86-a316-86b48069c4af
Source identifiers:
32548
Local pid:
pubs:32548

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