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Functional characterization of 4 polymorphisms in promoter region of hepatic lipase gene.

Abstract:

Hepatic lipase (HL) is a lipolytic enzyme involved in the metabolism of plasma lipoproteins, especially high density lipoproteins. Association studies have provided strong evidence for relations of common mutations in the promoter region of the HL gene to postheparin plasma HL activity and the plasma high density lipoprotein cholesterol concentration, but the functional relevance of these polymorphisms has not been evaluated to date. We analyzed the physiological significance of 4 common poly...

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Publication status:
Published

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Publisher copy:
10.1161/01.atv.20.5.1335

Authors


van't Hooft, FM More by this author
Lundahl, B More by this author
Ragogna, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Olivecrona, G More by this author
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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
20
Issue:
5
Pages:
1335-1339
Publication date:
2000-05-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:cd960fdc-468e-4c0b-a49d-bf1c13ff25d9
Source identifiers:
9217
Local pid:
pubs:9217

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