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A Wars2 mutant mouse model displays OXPHOS deficiencies and activation of tissue-specific stress response pathways

Abstract:

Mutations in genes essential for mitochondrial function have pleiotropic effects. The mechanisms underlying these traits yield insights into metabolic homeostasis and potential therapies. Here we report the characterization of a mouse model harboring a mutation in the tryptophanyl-tRNA synthetase 2 (Wars2) gene, encoding the mitochondrial-localized WARS2 protein. This hypomorphic allele causes progressive tissue-specific pathologies, including hearing loss, reduced adiposity, adipose tissue d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.11.080

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Wellcome Trust More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
25
Issue:
12
Pages:
3315-3328.e6
Publication date:
2018-12-18
Acceptance date:
2018-11-21
DOI:
ISSN:
2211-1247
Pmid:
30566859
Source identifiers:
952803
Language:
English
Keywords:
Pubs id:
pubs:952803
UUID:
uuid:cd945b47-ef17-4518-9c05-2cbf4b75893e
Local pid:
pubs:952803
Deposit date:
2019-01-18

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