A Wars2 mutant mouse model displays OXPHOS deficiencies and activation of tissue-specific stress response pathways
Mutations in genes essential for mitochondrial function have pleiotropic effects. The mechanisms underlying these traits yield insights into metabolic homeostasis and potential therapies. Here we report the characterization of a mouse model harboring a mutation in the tryptophanyl-tRNA synthetase 2 (Wars2) gene, encoding the mitochondrial-localized WARS2 protein. This hypomorphic allele causes progressive tissue-specific pathologies, including hearing loss, reduced adiposity, adipose tissue d...Expand abstract
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Copyright © 2018 The Authors.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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