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The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.

Abstract:

In this paper we show that DNA polymerase lambda (pol lambda) interacts with proliferating cell nuclear antigen (PCNA) in vivo in human cells. Moreover, by using recombinant mutated PCNA, we could demonstrate that pol lambda interacts with both the interdomain-connecting loop and the nearby hydrophobic pocket on the anterior of PCNA and that critical residues within a helix-hairpin-helix domain of pol lambda, important for proper DNA primer binding, are also involved in the enzyme's interacti...

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Publication status:
Published

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Publisher copy:
10.1096/fj.04-2268fje

Authors


Shevelev, I More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
18
Issue:
14
Pages:
1743-1745
Publication date:
2004-11-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:cd93c502-1938-47ae-b46a-72e4b78a4f69
Source identifiers:
417378
Local pid:
pubs:417378

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