- Abstract:
-
In this paper we show that DNA polymerase lambda (pol lambda) interacts with proliferating cell nuclear antigen (PCNA) in vivo in human cells. Moreover, by using recombinant mutated PCNA, we could demonstrate that pol lambda interacts with both the interdomain-connecting loop and the nearby hydrophobic pocket on the anterior of PCNA and that critical residues within a helix-hairpin-helix domain of pol lambda, important for proper DNA primer binding, are also involved in the enzyme's interacti...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1096/fj.04-2268fje
-
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- Journal:
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Volume:
- 18
- Issue:
- 14
- Pages:
- 1743-1745
- Publication date:
- 2004-11-05
- DOI:
- EISSN:
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1530-6860
- ISSN:
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0892-6638
- URN:
-
uuid:cd93c502-1938-47ae-b46a-72e4b78a4f69
- Source identifiers:
-
417378
- Local pid:
- pubs:417378
- Copyright date:
- 2004
Journal article
The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.
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