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Genetic heterogeneity of Australian Candida auris isolates: insights from a nonoutbreak setting using whole-genome sequencing

Abstract:
Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ofid/ofaa158

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0001-5095-6367
Publisher:
Oxford University Press
Journal:
Open Forum Infectious Diseases More from this journal
Volume:
7
Issue:
5
Article number:
ofaa158
Publication date:
2020-05-07
Acceptance date:
2020-04-29
DOI:
EISSN:
2328-8957
Pmid:
32500091
Language:
English
Keywords:
Pubs id:
1109961
Local pid:
pubs:1109961
Deposit date:
2020-10-26

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