Journal article
The centriolar cartwheel structure: symmetric, stacked, and polarized
- Abstract:
- An accurate centriolar structure is crucial for organelle function, necessitating the existence of molecular mechanisms for the tight control of centriole assembly. Formation of an initial scaffold, the cartwheel, assists the correct placement of centriolar proteins during assembly and templates key structural parameters of the organelle. Past work illustrated how cartwheel and centriolar symmetry are linked, and grounded organelle symmetry and diameter to the properties of the centriolar protein SAS-6. However, questions remained over how centriole polarity and length are controlled. Recent advances in resolving cartwheel structure and cell biology showed that these assemblies are polarized and that their length is under the control of a homeostatic mechanism. These cartwheel properties may, in turn, influence the centriolar polarity and length.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 5.9MB, Terms of use)
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- Publisher copy:
- 10.1016/j.sbi.2020.08.007
Authors
- Publisher:
- Elsevier
- Journal:
- Current Opinion in Structural Biology More from this journal
- Volume:
- 66
- Pages:
- 1-7
- Publication date:
- 2020-09-18
- Acceptance date:
- 2020-08-25
- DOI:
- ISSN:
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0959-440X
- Language:
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English
- Pubs id:
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1128374
- Local pid:
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pubs:1128374
- Deposit date:
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2020-08-26
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Elsevier Ltd. All rights reserved.
- Notes:
-
This is the accepted manuscript version of the article. The final version is available from Elsevier at https://doi.org/10.1016/j.sbi.2020.08.007
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