Measured haplotype analysis of the aldosterone synthase gene and heart size.

Journal article

Gene-association studies of heart size and the aldosterone synthase (CYP11B2) gene have produced inconsistent results, possibly because of limitations in the sample size and/or the number and location of the polymorphisms. An analysis of six polymorphisms spanning 6 kb of the CYP11B2 gene in Caucasian British families revealed a limited number of haplotypes because of strong linkage disequilibrium over this small region. The genotype and haplotype information was used in an association study ...

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Authors: Mayosi, B; Keavney, B; Watkins, H; Farrall, M

• Publication status: Published
• Journal: European journal of human genetics : EJHG
• Volume: 11
• Issue: 5
• Pages: 395-401
• Publication date: 2003-05-01
• DOI: 10.1038/sj.ejhg.5200967
• EISSN: 1476-5438
• ISSN: 1018-4813
• Language: English
• Keywords: Sequence Analysis, DNA; Polymorphism, Genetic; Heart; Humans; Female; Male; Aldosterone Synthase; Quantitative Trait Loci; Haplotypes; Genetic Markers; Middle Aged