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Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes

Abstract:

The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria. Previous analysis of data from the International HapMap Project indicated that a CD36 haplotype bearing a nonsense mutation (T1264G; rs3211938) had undergone recent positive selection in the Yoruba of Nigeria. To investigate the global distribution of this putative selection event, we genotyped T1264G in 3420 individuals from 66 populations. We confi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddp192

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Funding agency for:
Williams, T
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Funding agency for:
Williams, T
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Funding agency for:
Williams, T
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Funding agency for:
Kwiatkowski, D
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Publisher:
Oxford University Press Publisher's website
Journal:
Hum Mol Genet Journal website
Volume:
18
Issue:
14
Pages:
2683-2692
Publication date:
2009-01-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Source identifiers:
34702

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