Journal article icon

Journal article

Asymmetric total synthesis of (−)-(3R)-inthomycin C

Abstract:

A short (10 step) and efficient (15% overall yield) synthesis of the natural product (−)-(3R)-inthomycin C is reported. The key steps comprise three C–C bond-forming reactions: (i) a vinylogous Mukaiyama aldol, (ii) an olefin cross-metathesis reaction, and (iii) an asymmetric Mukaiyama–Kiyooka aldol. This route is notable for its brevity and has the advantage of lacking stoichiometric tin-promoted cross-coupling reactions present in previous approaches. Initial investigations on the biologica...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1021/acs.orglett.8b01370

Authors


Balcells, S More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Walker, JCL More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Expand authors...
More from this funder
Funding agency for:
Josa-Cullere, L
More from this funder
Funding agency for:
Towers, C
Publisher:
American Chemical Society Publisher's website
Journal:
Organic Letters Journal website
Volume:
20
Issue:
12
Pages:
3583–3586
Publication date:
2018-06-04
Acceptance date:
2018-05-25
DOI:
ISSN:
1523-7052
Pubs id:
pubs:857016
URN:
uri:cd7995aa-ec45-40df-bf0f-d6033e8f35ee
UUID:
uuid:cd7995aa-ec45-40df-bf0f-d6033e8f35ee
Local pid:
pubs:857016

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP