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Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain.

Abstract:

The A4VAR is a variant antigen expressed by a clonal line that binds CD36 and intercellular adhesion molecule-1, ICAM-1. We have cloned and sequenced the extracellular domain coded by the A4var gene. To probe the relationship between A4var expression and parasite adhesion to ICAM-1, var mRNA and protein expression were analyzed in an enriched population of A4 parasites that displayed higher ICAM-1 binding. By Northern analyses, A4var was the predominant var message and antisera raised against...

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Publication status:
Published

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Authors


Hudson-Taylor, D More by this author
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Journal:
Molecular and biochemical parasitology
Volume:
97
Issue:
1-2
Pages:
133-148
Publication date:
1998-11-05
DOI:
EISSN:
1872-9428
ISSN:
0166-6851
URN:
uuid:cd77c9dd-5e3c-488f-ab31-77c7cfb5b3d0
Source identifiers:
23886
Local pid:
pubs:23886

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