Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov, O; Castex, J; Tallant, C; Owen, D; Martin, S; Aldeghi, M; Monteiro, O; Filippakopoulos, P; Picaud, S; Trzupek, J; Gerstenberger, B; Bountra, C; Willmann, D; Wells, C; Philpott, M; Rogers, C; Biggin, P; Brennan, P; Bunnage, M; Schüle, R; Günther, T; Knapp, S; Müller, S

Journal article

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Abstract:: Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily conserved chromatin-remodeling complexes regulating gene transcription programs during development and stem cell differentiation. BAF complexes contain an ATP (adenosine 5'-triphosphate)-driven remodeling enzyme (either BRG1 or BRM) and multiple protein interaction domains including bromodomains, an evolutionary conserved acetyl lysine-dependent protein interaction motif that recruits transcriptional regul...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Fedorov, O., Castex, J., Tallant, C., Owen, D., Martin, S., Aldeghi, M., Monteiro, O., Filippakopoulos, P., Picaud, S., Trzupek, J., Gerstenberger, B., Bountra, C., Willmann, D., Wells, C., Philpott, M., Rogers, C., Biggin, P., Brennan, P., Bunnage, M., … Müller, S. (2015). Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance. Science Advances, 1(10), e1500723.

MLA Style

Fedorov, O., et al. “Selective Targeting of the BRG/PB1 Bromodomains Impairs Embryonic and Trophoblast Stem Cell Maintenance.” Science Advances, vol. 1, no. 10, American Association for the Advancement of Science, 2015, p. e1500723.

Chicago Style

Fedorov, O, J Castex, C Tallant, D Owen, S Martin, M Aldeghi, O Monteiro, et al. 2015. “Selective Targeting of the BRG/PB1 Bromodomains Impairs Embryonic and Trophoblast Stem Cell Maintenance.” Science Advances 1 (10): e1500723.
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Publisher copy:: 10.1126/sciadv.1500723

Authors

+ Fedorov, O More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Structural Genomics Consortium

Role:

Author

+ Castex, J More by this author

Role:

Author

+ Tallant, C More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Structural Genomics Consortium

Role:

Author

+ Owen, D More by this author

Role:

Author

+ Martin, S More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Structural Genomics Consortium

Role:

Author

More authors...

Funding

+ Wellcome Trust More from this funder

Funding agency for:

Filippakopoulos, P

Picaud, S

Grant:

Career Development Fellowship (095751/Z/11/Z)

+ Doctoral Training Centre More from this funder

Funding agency for:

Aldeghi, M

+ Engineering and Physical Sciences Research Council More from this funder

Funding agency for:

Aldeghi, M

Structural Genomics Consortium More from this funder

Bibliographic Details

Publisher:: American Association for the Advancement of Science Publisher's website
Journal:: Science advances Journal website
Volume:: 1
Issue:: 10
Pages:: e1500723
Publication date:: 2015-11-13
DOI:: 10.1126/sciadv.1500723
EISSN:: 2375-2548

Item Description

Language:: English
Keywords:: BRM

chromatin remodelling,embryonic stem cells

chemical probe

BAF complex

trophoblast stem cells

epigenetics

PB1

BRG
Pubs id:: pubs:586284
UUID:: uuid:cd5bb46a-0b27-4b2a-a7c8-baad26dc7ed5
Local pid:: pubs:586284
Source identifiers:: 586284
Deposit date:: 2016-01-15

Terms of use

Copyright holder:: Fedorov et al
Notes:: 2015 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution License 4.0. This is the publisher's version of the article. The final version is available online from the American Association for the Advancement of Science at: [10.1126/sciadv.1500723].

Licence:: CC Attribution (CC BY)

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Journal article

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

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