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Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.

Abstract:

APE1 (Ref-1) is an essential human protein involved in DNA damage repair and regulation of transcription. Although the cellular functions and biochemical properties of APE1 are well characterized, the mechanism involved in regulation of the cellular levels of this important DNA repair/transcriptional regulation enzyme, remains poorly understood. Using an in vitro ubiquitylation assay, we have now purified the human E3 ubiquitin ligase UBR3 as a major activity that polyubiquitylates APE1 at mu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkr744

Authors


Meisenberg, C More by this author
Dianova, II More by this author
Edelmann, MJ More by this author
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Funding agency for:
Dianov, GL
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
40
Issue:
2
Pages:
701-711
Publication date:
2012-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:cd52062f-cfa8-4fad-9398-62e7c3d267e3
Source identifiers:
180454
Local pid:
pubs:180454

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