Journal article
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
- Abstract:
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APE1 (Ref-1) is an essential human protein involved in DNA damage repair and regulation of transcription. Although the cellular functions and biochemical properties of APE1 are well characterized, the mechanism involved in regulation of the cellular levels of this important DNA repair/transcriptional regulation enzyme, remains poorly understood. Using an in vitro ubiquitylation assay, we have now purified the human E3 ubiquitin ligase UBR3 as a major activity that polyubiquitylates APE1 at mu...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.8MB)
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- Publisher copy:
- 10.1093/nar/gkr744
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic acids research Journal website
- Volume:
- 40
- Issue:
- 2
- Pages:
- 701-711
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
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0305-1048
- Source identifiers:
-
180454
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:cd52062f-cfa8-4fad-9398-62e7c3d267e3
- Local pid:
- pubs:180454
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Meisenberg et al
- Copyright date:
- 2012
- Notes:
- Copyright © 2011 Meisenberg et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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