Osteoclastic differentiation by mononuclear phagocytes containing biomaterial particles.

Journal article

Aseptic loosening of implant components is a common and important complication of both cemented and uncemented prosthetic joint replacements. Wear particles derived from organic polymer and metal implant biomaterials are commonly found within macrophages and macrophage polykaryons in the fibrous membrane between loose implant components and the host bone undergoing resorption. In order to determine whether biomaterial particle-containing, foreign-body macrophages may contribute to periprosthe...

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Authors: Sabokbar, A; Pandey, R; Quinn, J; Athanasou, N

• Publication status: Published
• Journal: Archives of orthopaedic and trauma surgery
• Volume: 117
• Issue: 3
• Pages: 136-140
• Publication date: 1998-01-01
• DOI: 10.1007/s004020050213
• EISSN: 1434-3916
• ISSN: 0936-8051
• Language: English
• Keywords: Particle Size; Cell Differentiation; Biocompatible Materials; Animals; Phagocytes; Bone and Bones; Osteoclasts; Mice; Prosthesis Failure; Foreign Bodies; Joint Prosthesis; Humans; Culture Techniques; Bone Resorption