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Journal article

High frequency of HIV mutations associated with HLA-C suggests enhanced HLA-C-restricted CTL selective pressure associated with an AIDS-protective polymorphism.

Abstract:

Delayed HIV-1 disease progression is associated with a single nucleotide polymorphism upstream of the HLA-C gene that correlates with differential expression of the HLA-C Ag. This polymorphism was recently shown to be a marker for a protective variant in the 3'UTR of HLA-C that disrupts a microRNA binding site, resulting in enhanced HLA-C expression at the cell surface. Whether individuals with "high" HLA-C expression show a stronger HLA-C-restricted immune response exerting better viral cont...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1103472

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Journal of Immunology More from this journal
Volume:
188
Issue:
9
Pages:
4663-4670
Publication date:
2012-05-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Language:
English
Keywords:
Pubs id:
pubs:322680
UUID:
uuid:cd464b5d-083d-48c6-9375-b31edd684d1d
Local pid:
pubs:322680
Source identifiers:
322680
Deposit date:
2012-12-19

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