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Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies

Abstract:

Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohort...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep35842

Authors


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Name:
Fondo de Investigación Sanitaria
Grant:
delplannacionaldeI + D + I
‘fondosFEDER’
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Name:
Convenio de colaboración de investigación
Grant:
Novartis España-Fundación IDICHUS 2010–2011
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Name:
Consellería de Sanidade - Xunta de Galicia
Grant:
RHI07/2-intensificaciónactividadinvestigadora,PS09749
10PXIB918184PR
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Name:
Instituto de Salud Carlos III
Grant:
Intensificación de la actividad investigadora 2007–2012, PI16/01569
Publisher:
Nature Publishing Group
Journal:
Scientific Reports More from this journal
Volume:
6
Article number:
35842
Publication date:
2016-11-02
Acceptance date:
2016-10-06
DOI:
ISSN:
2045-2322
Keywords:
Pubs id:
pubs:661431
UUID:
uuid:cd44ee9c-4c09-4d41-81d5-050dd46d8958
Local pid:
pubs:661431
Source identifiers:
661431
Deposit date:
2016-11-26

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