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Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies

Abstract:

Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohort...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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10.1038/srep35842

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Grant:
Proyecto de Investigación en Salud, Acción Estratégica en Salud: proyecto GePEM PI16/01478
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Grant:
RHI07/2-intensificación actividad investigadora, PS09749 and 10PXIB918184PR
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Grant:
Wyeth España-Fundación IDICHUS 2007–2011
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
Article: 35842
Publication date:
2016-11-02
DOI:
ISSN:
2045-2322
Pubs id:
pubs:661431
URN:
uri:cd44ee9c-4c09-4d41-81d5-050dd46d8958
UUID:
uuid:cd44ee9c-4c09-4d41-81d5-050dd46d8958
Local pid:
pubs:661431
Keywords:

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