Journal article
High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease.
- Abstract:
-
MHC class I-restricted CD8 cytotoxic T lymphocytes (CTL) are essential for protective immunity to Mycobacterium tuberculosis in animal models but their role in humans remains unclear. We therefore studied subjects who had successfully contained M. tuberculosis infection in vivo, i.e. exposed healthy household contacts and individuals with inactive self-healed pulmonary tuberculosis. Using the ELISPOT assay for IFN-gamma, we screened peptides from ESAT-6, a secreted antigen that is highly spec...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/1521-4141(200009)30:9<2713::AID-IMMU2713>3.0.CO;2-4
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 30
- Issue:
- 9
- Pages:
- 2713-2721
- Publication date:
- 2000-09-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
31756
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:31756
- UUID:
-
uuid:cd424d4b-d837-4977-a0a0-77980403ae05
- Local pid:
- pubs:31756
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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