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High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease.

Abstract:

MHC class I-restricted CD8 cytotoxic T lymphocytes (CTL) are essential for protective immunity to Mycobacterium tuberculosis in animal models but their role in humans remains unclear. We therefore studied subjects who had successfully contained M. tuberculosis infection in vivo, i.e. exposed healthy household contacts and individuals with inactive self-healed pulmonary tuberculosis. Using the ELISPOT assay for IFN-gamma, we screened peptides from ESAT-6, a secreted antigen that is highly spec...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
Role:
Author
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Journal:
European journal of immunology
Volume:
30
Issue:
9
Pages:
2713-2721
Publication date:
2000-09-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:cd424d4b-d837-4977-a0a0-77980403ae05
Source identifiers:
31756
Local pid:
pubs:31756

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