- Abstract:
-
MHC class I-restricted CD8 cytotoxic T lymphocytes (CTL) are essential for protective immunity to Mycobacterium tuberculosis in animal models but their role in humans remains unclear. We therefore studied subjects who had successfully contained M. tuberculosis infection in vivo, i.e. exposed healthy household contacts and individuals with inactive self-healed pulmonary tuberculosis. Using the ELISPOT assay for IFN-gamma, we screened peptides from ESAT-6, a secreted antigen that is highly spec...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/1521-4141(200009)30:9<2713::AID-IMMU2713>3.0.CO;2-4
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- Journal:
- European journal of immunology
- Volume:
- 30
- Issue:
- 9
- Pages:
- 2713-2721
- Publication date:
- 2000-09-05
- DOI:
- EISSN:
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1521-4141
- ISSN:
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0014-2980
- URN:
-
uuid:cd424d4b-d837-4977-a0a0-77980403ae05
- Source identifiers:
-
31756
- Local pid:
- pubs:31756
- Copyright date:
- 2000
Journal article
High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease.
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