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The clinical outcome and toxicity of high-dose chemotherapy and autologous stem cell transplantation in patients with myeloma or amyloid and severe renal impairment: a British Society of Blood and Marrow Transplantation study.

Abstract:

The outcome of high-dose chemotherapy (HDT) was evaluated retrospectively in 27 patients with myeloma and four patients with AL amyloidosis with severe renal impairment. Twenty-three patients were receiving dialysis and the rest had a creatinine clearance of <20 ml/min. The median melphalan dose was 140 mg/m2 (range: 60-200 mg/m2), but 10 patients (37%) received 200 mg/m2. Myeloid and platelet engraftment were similar to that seen in patients without renal failure. Five of 27 patients died...

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Publication status:
Published

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Authors


Apperley, JF More by this author
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Journal:
British journal of haematology
Volume:
134
Issue:
4
Pages:
385-390
Publication date:
2006-08-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:cd32964c-c9b1-47ae-a445-15192b5960d6
Source identifiers:
222879
Local pid:
pubs:222879

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