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Therapeutic potential of monovalent monoclonal antibodies.

Abstract:

One therapeutic use for monoclonal antibody technology is the elimination of categories of unwanted cells by virtue of their distinct cell surface antigens. The efficiency of cell destruction by complement lysis or opsonization depends on a number of factors such as antibody specificity and isotype as well as certain properties of the target antigen. In some instances cells can escape destruction by redistributing and eventually losing the antigen-antibody complexes from their surface. This p...

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Publication status:
Published

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Publisher copy:
10.1038/308460a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nature
Volume:
308
Issue:
5958
Pages:
460-462
Publication date:
1984
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:cd262b24-cee1-469c-8ccc-6361188ca5d4
Source identifiers:
14365
Local pid:
pubs:14365

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