Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance

Journal article

To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from the Goto-Kakizaki (GK) rat model of type 2 diabetes and normoglycaemic Brown Norway (BN) rats. We mapped 2526 statistically significant expression quantitative trait loci (eQTLs) in the cross. More than 40% of eQTLs mapped in the close vicinity of t...

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Authors: Otto, GW; Kaisaki, PJ; Brial, F; Le Lay, A; Cazier, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: The Company of Biologists
• Journal: Disease Models & Mechanisms
• Volume: 12
• Issue: 7
• Article number: dmm038539
• Publication date: 2019-07-15
• Acceptance date: 2019-05-20
• DOI: 10.1242/dmm.038539
• EISSN: 1754-8411
• ISSN: 1754-8403
• Language: English
• Keywords: Systems genetics; Goto-Kakizaki rat; Diabetes mellitus; Spontaneously hypertensive rat; Transcriptome; eQTL; SNP