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Hydration and interactions in protein solutions containing concentrated electrolytes studied by small-angle scattering

Abstract:

During protein crystallization and purification, proteins are commonly found in concentrated salt solutions. The exact interplay of the hydration shell, the salt ions, and protein-protein interactions under these conditions is far from being understood on a fundamental level, despite the obvious practical relevance. We have studied a model globular protein (bovine serum albumin, BSA) in concentrated salt solutions by small-angle neutron scattering (SANS). The data are also compared to previou...

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Publisher copy:
10.1039/c2cp23460b

Authors


Journal:
Physical Chemistry Chemical Physics More from this journal
Volume:
14
Issue:
7
Pages:
2483-2493
Publication date:
2012-02-21
DOI:
EISSN:
1463-9084
ISSN:
1463-9076
Language:
English
Pubs id:
pubs:343300
UUID:
uuid:cd237644-c3b1-4496-aa9e-aba537549707
Local pid:
pubs:343300
Source identifiers:
343300
Deposit date:
2012-12-19

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