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Journal article

P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer.

Abstract:
Raised levels of P/Q type voltage-gated calcium-channel (VGCC) antibodies were found in 16 (41%) of 39 patients with paraneoplastic cerebellar degeneration (PCD) and Hu antibodies were found in nine (23%). Seven of the 16 VGCC antibody-positive patients had Lambert-Eaton myasthenic syndrome (LEMS). Seven of 15 CSF samples had VGCC antibodies, with evidence of intrathecal synthesis in four. VGCC antibodies should be looked for in PCD, even if there are no symptoms of LEMS, and may be related to the cerebellar dysfunction.
Publication status:
Published

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Publisher copy:
10.1212/wnl.59.5.764

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Pozo-Rosich, P More by this author
Casamitjana, R More by this author
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Journal:
Neurology
Volume:
59
Issue:
5
Pages:
764-766
Publication date:
2002-09-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:cd200585-72da-458c-9527-04fbd84d9f40
Source identifiers:
242547
Local pid:
pubs:242547

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