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Characterisation of the global transcriptional response to heat shock and the impact of individual genetic variation

Abstract:

Background. The heat shock transcriptional response is essential to effective cellular function under stress. This is a highly heritable trait but the nature and extent of inter-individual variation in heat shock response remains unresolved. Methods. We determined global transcription profiles of the heat shock response for a panel of lymphoblastoid cell lines established from 60 founder individuals in the Yoruba HapMap population. We explore the observed differentially expressed gene sets fo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13073-016-0345-5

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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
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Funding agency for:
Knight, Julian
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Funding agency for:
Knight, Julian
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Funding agency for:
Knight, Julian
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Grant:
074318; 075491/Z/04/
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Publisher:
BioMed Central Publisher's website
Journal:
Genome Medicine Journal website
Volume:
8
Issue:
1
Pages:
Article: 87
Publication date:
2016-01-01
Acceptance date:
2016-07-25
DOI:
ISSN:
1756-994X
Pubs id:
pubs:637968
URN:
uri:cd1b1b6b-9748-4a60-91db-83d61dd79dfa
UUID:
cd1b1b6b-9748-4a60-91db-83d61dd79dfa
Local pid:
pubs:637968
Paper number:
1

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