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Virulence in malaria: an evolutionary viewpoint.

Abstract:

Malaria parasites cause much morbidity and mortality to their human hosts. From our evolutionary perspective, this is because virulence is positively associated with parasite transmission rate. Natural selection therefore drives virulence upwards, but only to the point where the cost to transmission caused by host death begins to outweigh the transmission benefits. In this review, we summarize data from the laboratory rodent malaria model, Plasmodium chabaudi, and field data on the human mala...

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Publisher copy:
10.1098/rstb.2003.1414

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
359
Issue:
1446
Pages:
965-986
Publication date:
2004-06-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:cd14847e-49aa-47b4-8006-3cda5a8b48c9
Source identifiers:
139155
Local pid:
pubs:139155

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