Virulence in malaria: an evolutionary viewpoint.
Malaria parasites cause much morbidity and mortality to their human hosts. From our evolutionary perspective, this is because virulence is positively associated with parasite transmission rate. Natural selection therefore drives virulence upwards, but only to the point where the cost to transmission caused by host death begins to outweigh the transmission benefits. In this review, we summarize data from the laboratory rodent malaria model, Plasmodium chabaudi, and field data on the human mala...Expand abstract
- Publisher copy:
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- Publication date:
- Source identifiers:
- Local pid:
- Copyright date: