- Abstract:
-
Long-lived plasma cells (PCs) develop in germinal centers (GCs) by the differentiation of affinity matured B cells. Antibody affinity maturation involves iterative rounds of somatic hypermutation in dark zones (DZs) and selection in light zones (LZs), however the details of where, when and how PC commitment occurs are not well-understood. Fate bifurcation at the time of selection is one possibility, with the very highest affinity GC B cells differentiating as an alternative to DZ re-entry. Ho...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 11.9MB)
-
- Publisher copy:
- 10.3389/fimmu.2018.03106
-
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- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 9
- Pages:
- 3106
- Publication date:
- 2019-01-09
- Acceptance date:
- 2018-12-17
- DOI:
- EISSN:
-
1664-3224
- Pubs id:
-
pubs:955403
- URN:
-
uri:cd134946-3fd4-4725-a6a3-64d3dac6cd39
- UUID:
-
uuid:cd134946-3fd4-4725-a6a3-64d3dac6cd39
- Local pid:
- pubs:955403
- Copyright holder:
- Radtke et al.
- Copyright date:
- 2019
- Notes:
- © 2019 Radtke and Bannard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Journal article
Expression of the plasma cell transcriptional regulator Blimp-1 by dark zone germinal center B cells during periods of proliferation
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