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Expression of the plasma cell transcriptional regulator Blimp-1 by dark zone germinal center B cells during periods of proliferation

Abstract:

Long-lived plasma cells (PCs) develop in germinal centers (GCs) by the differentiation of affinity matured B cells. Antibody affinity maturation involves iterative rounds of somatic hypermutation in dark zones (DZs) and selection in light zones (LZs), however the details of where, when and how PC commitment occurs are not well-understood. Fate bifurcation at the time of selection is one possibility, with the very highest affinity GC B cells differentiating as an alternative to DZ re-entry. Ho...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2018.03106

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
3106
Publication date:
2019-01-09
Acceptance date:
2018-12-17
DOI:
EISSN:
1664-3224
Keywords:
Pubs id:
pubs:955403
UUID:
uuid:cd134946-3fd4-4725-a6a3-64d3dac6cd39
Local pid:
pubs:955403
Deposit date:
2019-01-03

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