Structural insights into the Fanconi Anaemia pathway

Thesis

The human genome is subject to numerous endogenous and exogenous stresses that cause a variety of DNA damage and has thus evolved a complex DNA damage response (DDR). Within this DDR are a number of DNA repair pathways, which have evolved to repair different types of DNA damage. One such mechanism is the Fanconi Anaemia (FA) pathway, which repairs interstrand crosslinks (ICLs). Crucial to the activation of this pathway is the recognition of the ICL, and the subsequent recruitment and ubiqu...

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Authors: Lipp, C

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English