The development of functional hyaluronan hydrogels for neural tissue engineering

Thesis

Tissue engineers – in order to develop therapies for the treatment of complex neurological injuries and diseases – attempt to recreate elaborate developmental mechanisms in vitro. Neuronal precursor cells are excellent candidates for the study of developmental operations such as cell adhesion, differentiation, and axonal pathfinding. Hyaluronan (HA) is a common polysaccharide that is found extensively throughout the neuronal extracellular matrix (ECM), and can be functionalised an...

Expand abstract

Authors: Putter, P

• Publication date: 2015
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: biomimetics; trauma; hydrogel; stem cell; hyaluronan; hyaluronic acid; SANS; traumatic; neural; regenerative medicine; neuronal; neural network; tissue engineering; brain injury
• Subjects: Materials engineering; Advanced materials; Medical Engineering; Cell Biology (see also Plant sciences); Biomedical engineering; Polymers Amino acid and peptide chemistry; Muscle & Nerve (Neuroscience)