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The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Abstract:

Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant production of succinate, formaldehyde, and carbon dioxide. Consistent with a potential role in nucleic a...

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Publication status:
Published

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Publisher copy:
10.1126/science.1151710

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Journal:
Science (New York, N.Y.)
Volume:
318
Issue:
5855
Pages:
1469-1472
Publication date:
2007-11-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:cd012682-c3f1-46f9-9edb-060c9a6668c5
Source identifiers:
8988
Local pid:
pubs:8988

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