- Abstract:
-
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate-dependent oxygenases. We find that recombinant murine Fto catalyzes the Fe(II)- and 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA, with concomitant production of succinate, formaldehyde, and carbon dioxide. Consistent with a potential role in nucleic a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1126/science.1151710
-
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- Journal:
- Science (New York, N.Y.)
- Volume:
- 318
- Issue:
- 5855
- Pages:
- 1469-1472
- Publication date:
- 2007-11-05
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- URN:
-
uuid:cd012682-c3f1-46f9-9edb-060c9a6668c5
- Source identifiers:
-
8988
- Local pid:
- pubs:8988
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
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