Journal article
Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif.
- Abstract:
-
Human APOBEC3G (A3G) and APOBEC3F (A3F) inhibit the replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their degradation. Thus, the Vif-A3G and Vif-A3F interactions are attractive targets for antiviral drug development, as inhibiting these interactions could allow the host defense mechanism to control HIV-1 replication. Recently, it has been reported that amino acids 105 to 156 of A3G are...
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- Publisher copy:
- 10.1128/jvi.01621-08
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Bibliographic Details
- Journal:
- Journal of virology
- Volume:
- 83
- Issue:
- 4
- Pages:
- 1992-2003
- Publication date:
- 2009-02-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:cd00cbde-7912-4734-9b3a-a8e3a2edbfec
- Source identifiers:
-
237024
- Local pid:
- pubs:237024
Item Description
Terms of use
- Copyright date:
- 2009
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