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Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif.

Abstract:

Human APOBEC3G (A3G) and APOBEC3F (A3F) inhibit the replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their degradation. Thus, the Vif-A3G and Vif-A3F interactions are attractive targets for antiviral drug development, as inhibiting these interactions could allow the host defense mechanism to control HIV-1 replication. Recently, it has been reported that amino acids 105 to 156 of A3G are...

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Publisher copy:
10.1128/jvi.01621-08

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Bhattacharyya, D More by this author
Pathak, VK More by this author
Journal:
Journal of virology
Volume:
83
Issue:
4
Pages:
1992-2003
Publication date:
2009-02-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:cd00cbde-7912-4734-9b3a-a8e3a2edbfec
Source identifiers:
237024
Local pid:
pubs:237024

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