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Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein.

Abstract:

Fragile sites appear visually as nonstaining gaps on chromosomes that are inducible by specific cell culture conditions. Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A. In the present study we have refined the localization of the FRA10A folate-sensitive fragile site by fluorescence in situ hybridization. Sequence analysis of a BAC clone spanning FRA...

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Publisher copy:
10.1016/j.ygeno.2003.12.017

Authors


Sarafidou, T More by this author
Martinez-Garay, I More by this author
Mangelsdorf, M More by this author
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Journal:
Genomics
Volume:
84
Issue:
1
Pages:
69-81
Publication date:
2004-07-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:ccff8378-c7d5-4e44-9e72-a5d6337cd71c
Source identifiers:
426696
Local pid:
pubs:426696

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