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Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

Abstract:

BACKGROUND: Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in general versus a specific effect on prostate cancer only. METHODOLOGY/PRINCIPAL FINDINGS: In a collaborative analysis, we collected data from GWAS of cancer phenotypes for the frequently reported variants of HNF1B, rs4430796 and rs7501939, which...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0010858

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Gudmundsson, J More by this author
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Funding agency for:
Elliott, KS
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Funding agency for:
Zeggini, E
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Funding agency for:
Hamdy, FC
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
5
Pages:
e10858
Publication date:
2010
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:ccff164c-2558-43f7-863e-6244bf94ed08
Source identifiers:
60442
Local pid:
pubs:60442

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