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Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

Abstract:

BACKGROUND: Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in general versus a specific effect on prostate cancer only. METHODOLOGY/PRINCIPAL FINDINGS: In a collaborative analysis, we collected data from GWAS of cancer phenotypes for the frequently reported variants of HNF1B, rs4430796 and rs7501939, which...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0010858

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Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Name:
Wellcome Trust
Funding agency for:
Zeggini, E
Elliott, K
Grant:
WT088885/Z/09/Z
WT075491/Z/04
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Name:
Cancer Research UK
Funding agency for:
Hamdy, F
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Name:
Medical Research Council
Funding agency for:
Hamdy, F
More from this funder
Name:
Department of Health
Funding agency for:
Hamdy, F
More from this funder
Name:
National Cancer Research Institute
Funding agency for:
Hamdy, F
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
5
Issue:
5
Article number:
e10858
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
Pubs id:
pubs:60442
UUID:
uuid:ccff164c-2558-43f7-863e-6244bf94ed08
Local pid:
pubs:60442
Source identifiers:
60442
Deposit date:
2012-12-19

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