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On the role of APC-activation for in vitro versus in vivo T cell priming.

Abstract:

Professional antigen-presenting cells take up antigens for processing and presentation in association with MHC class I and II molecules. When APCs receive the right stimuli, they undergo a maturation process and migrate to secondary lymphoid organs to trigger T cell activation. In this study, we compared side-by-side in vivo and in vitro activation of T cells. Transgenic CD8(+) T cells specific for the p33 epitope, derived from the lymphocytic choriomeningitis virus glycoprotein, were labeled...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
Journal:
Cellular immunology
Volume:
225
Issue:
1
Pages:
1-11
Publication date:
2003-09-01
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
Source identifiers:
469783

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