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Role of macrophages in in vitro induction of T-helper cells.

Abstract:

In a set of experiments it was ascertained that macrophages incubated in the presence of antigen, for example, keyhole limpet hemocyanin (KLH), can release factor(s) able to induce specific helper cells to KLH. Supernatant taken from purified macrophages, which had been incubated with KLH for 4 days, adequately replaced macrophages and antigen when tested in the helper system. Thus in this system no direct contact between macrophages and T lymphocyte is necessary. Moreover, the supernatant ra...

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Publication status:
Published

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Publisher copy:
10.1038/254352a0

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Nature
Volume:
254
Issue:
5498
Pages:
352-354
Publication date:
1975-03-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
481873
Language:
English
Keywords:
Pubs id:
pubs:481873
UUID:
uuid:ccf4b5b4-b33f-4c20-8436-bfb8155e90d3
Local pid:
pubs:481873
Deposit date:
2014-08-29

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