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Phospholipase C-dependent Ca2+ release by worm and mammal sperm factors.

Abstract:

Egg activation in all animals evidently requires the synthesis of inositol 1,4,5-trisphosphate (InsP(3)) from phosphatidylinositol 4,5-bisphosphate (PIP(2)) by phospholipase C (PLC). Depending on the organism, InsP(3) elicits either calcium oscillations or a single wave, which in turn initiates development. A soluble component in boar sperm that activates mammalian eggs has been suggested to be a PLC isoform. We tested this hypothesis in vitro using egg microsomes of Chaetopterus. Boar sperm ...

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Publication status:
Published

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Authors


Howell, KP More by this author
Skipwith, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Eckberg, WR More by this author
Journal:
Biochemical and biophysical research communications
Volume:
307
Issue:
1
Pages:
47-51
Publication date:
2003-07-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:ccf28535-96dd-42d5-a6a7-51340639ae31
Source identifiers:
106187
Local pid:
pubs:106187

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