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Phospholipase C-dependent Ca2+ release by worm and mammal sperm factors.

Abstract:

Egg activation in all animals evidently requires the synthesis of inositol 1,4,5-trisphosphate (InsP(3)) from phosphatidylinositol 4,5-bisphosphate (PIP(2)) by phospholipase C (PLC). Depending on the organism, InsP(3) elicits either calcium oscillations or a single wave, which in turn initiates development. A soluble component in boar sperm that activates mammalian eggs has been suggested to be a PLC isoform. We tested this hypothesis in vitro using egg microsomes of Chaetopterus. Boar sperm ...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Biochemical and biophysical research communications
Volume:
307
Issue:
1
Pages:
47-51
Publication date:
2003-07-01
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
Source identifiers:
106187
Language:
English
Keywords:
Pubs id:
pubs:106187
UUID:
uuid:ccf28535-96dd-42d5-a6a7-51340639ae31
Local pid:
pubs:106187
Deposit date:
2012-12-19

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