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Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.

Abstract:

OBJECTIVES: Antimalarial combination therapy is used in persons with HIV infection in the absence of data on drug interactions. The objective of this study was to investigate the pharmacokinetics (PK) of antimalarial combination artemether/lumefantrine (AL) when administered with the protease inhibitor combination lopinavir/ritonavir (LPV/r) in HIV-uninfected healthy volunteers to determine if important drug interactions exist between these agents. DESIGN: Open-label study in healthy HIV-ser...

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Publication status:
Published

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Authors


Lawrence, J More by this author
Rosenthal, PJ More by this author
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Journal:
Journal of acquired immune deficiency syndromes (1999)
Volume:
51
Issue:
4
Pages:
424-429
Publication date:
2009-08-05
DOI:
EISSN:
1944-7884
ISSN:
1525-4135
URN:
uuid:ccf1b997-31ec-4917-b3cd-81e2cad9ac16
Source identifiers:
3580
Local pid:
pubs:3580

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