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Molecular tools for the study of ADP-ribosylation: a unified and versatile method to synthesise native mono-ADP-ribosylated peptides

Abstract:

ADP-ribosylation (ADPr), as a post-translational modification, plays a crucial role in DNA-repair, immunity and many other cellular and physiological processes. Serine is the main acceptor for ADPr in DNA damage response, whereas the physiological impact of less common ADPr-modifications of cysteine and threonine side chains is less clear. Generally, gaining molecular insights into ADPr recognition and turn-over is hampered by the availability of homogeneous, ADP-ribosylated material, such as...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/chem.202100337

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
210634/Z/18/Z
More from this funder
Name:
Cancer Research UK
Grant:
22284
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
BB/R007195/1
Publisher:
Wiley
Journal:
Chemistry - A European Journal More from this journal
Volume:
27
Issue:
41
Pages:
10621-10627
Publication date:
2021-05-06
Acceptance date:
2021-03-26
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Pmid:
33769608
Language:
English
Keywords:
Pubs id:
1170252
Local pid:
pubs:1170252
Deposit date:
2021-07-14

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