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Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation.

Abstract:

Chromatin remodeling is an important step in promoter activation during cellular lineage commitment and differentiation. We show that the ability of the C/EBPalpha transcription factor to direct adipocyte differentiation of uncommitted fibroblast precursors and to activate SWI/SNF-dependent myeloid-specific genes depends on a domain, C/EBPalpha transactivation element III (TE-III), that binds the SWI/SNF chromatin remodeling complex. TE-III collaborates with C/EBPalpha TBP/TFIIB interaction m...

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Publisher copy:
10.1101/gad.209901

Authors


Pedersen, TA More by this author
Kowenz-Leutz, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Molecular Medicine
Journal:
Genes and development
Volume:
15
Issue:
23
Pages:
3208-3216
Publication date:
2001-12-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:cce216e6-1be0-4299-86cd-07c7db9e02ef
Source identifiers:
324032
Local pid:
pubs:324032

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