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A dynamic view of the immunological synapse.

Abstract:

T cell activation requires interactions of T cell antigen receptors (TCR) and peptides presented by major histocompatibility complex molecules (MHCp) in an adhesive junction between the T cell and antigen-presenting cell. Stable junctions with bull's eye supramolecular activation clusters (SMACs) have been defined as immunological synapses (IS). These structures maintain T cell-APC interaction and allow directed secretion. T cells can also be activated by asymmetric hemi-synapses (HS) that al...

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Publisher copy:
10.1016/j.smim.2005.09.002

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Seminars in immunology
Volume:
17
Issue:
6
Pages:
400-410
Publication date:
2005-12-05
DOI:
EISSN:
1096-3618
ISSN:
1044-5323
URN:
uuid:ccdfe396-1b5b-4413-8594-8ac8885cd63e
Source identifiers:
482618
Local pid:
pubs:482618

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