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Axon routing at the optic chiasm after enzymatic removal of chondroitin sulfate in mouse embryos.

Abstract:

The effects of removing chondroitin sulfate from chondroitin sulfate proteoglycan molecules on guidance of retinal ganglion cell axons at the optic chiasm were investigated in a brain slice preparation of mouse embryos of embryonic day 13 to 15. Slices were grown for 5 hours and growth of dye-labeled axons was traced through the chiasm. After continuous enzymatic digestion of the chondroitin sulfate proteoglycans with chondroitinase ABC, which removes the glycosaminoglycan chains, navigation ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Development (Cambridge, England)
Volume:
127
Issue:
12
Pages:
2673-2683
Publication date:
2000-06-05
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:ccdf6280-6c85-4189-8822-cadc60ff1fd9
Source identifiers:
95091
Local pid:
pubs:95091

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