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Griseofulvin-induced aggregation of microtubule protein.

Abstract:

Griseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule protein. The supernatant obtained after removal of the griseofulvin-induced aggregate does not form microtubules on warming at 37 degrees C. Addition of the griseofulvin-aggregated protein to this supernatant and warming ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Pogson, CI More by this author
Journal:
The Biochemical journal
Volume:
167
Issue:
1
Pages:
39-43
Publication date:
1977-10-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:ccddee0d-01d3-4f06-ae42-601d7c5adef9
Source identifiers:
22880
Local pid:
pubs:22880

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