Limited spatial clustering of individual Plasmodium falciparum alleles in field isolates from coastal Kenya.

Journal article

We describe Plasmodium falciparum genetic diversity in coastal Kenya, typing S-antigen and the merozoite surface proteins 1 and 2 (MSP-1 and MSP-2) in field isolates by the polymerase chain reaction (PCR). Malaria in coastal Kenya is characterized by low seasonal transmission, and a relatively high incidence of severe disease, which tends to occur in time-space clusters. We chose the highly polymorphic S-antigen as a marker for localized parasite diversity because it has been shown to vary in...

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Authors: Kyes, S; Harding, R; Black, G; Craig, A; Peshu, N

• Publication status: Published
• Journal: American journal of tropical medicine and hygiene
• Volume: 57
• Issue: 2
• Pages: 205-215
• Publication date: 1997-08-01
• EISSN: 1476-1645
• ISSN: 0002-9637
• Language: English
• Keywords: Merozoite Surface Protein 1; Animals; Protein Precursors; Sequence Analysis, DNA; Prevalence; Infant, Newborn; Plasmodium falciparum; Malaria, Falciparum; Time Factors; Infant; Antigens, Protozoan; Humans; Polymerase Chain Reaction; Sensitivity and Specificity; Age Factors; Longitudinal Studies; Kenya; Cross-Sectional Studies; Genes, Protozoan; Polymorphism, Genetic; Child, Preschool; Molecular Epidemiology; Alleles; Child; Protozoan Proteins