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Limited spatial clustering of individual Plasmodium falciparum alleles in field isolates from coastal Kenya.

Abstract:

We describe Plasmodium falciparum genetic diversity in coastal Kenya, typing S-antigen and the merozoite surface proteins 1 and 2 (MSP-1 and MSP-2) in field isolates by the polymerase chain reaction (PCR). Malaria in coastal Kenya is characterized by low seasonal transmission, and a relatively high incidence of severe disease, which tends to occur in time-space clusters. We chose the highly polymorphic S-antigen as a marker for localized parasite diversity because it has been shown to vary in...

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Publication status:
Published

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Journal:
American journal of tropical medicine and hygiene More from this journal
Volume:
57
Issue:
2
Pages:
205-215
Publication date:
1997-08-01
EISSN:
1476-1645
ISSN:
0002-9637

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