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A multigenerational family with multiple sclerosis.

Abstract:

We report a family with 15 individuals affected with multiple sclerosis present in three and possibly four generations. The segregation of multiple sclerosis within this pedigree is consistent with an autosomal dominant mode of inheritance with reduced penetrance. The clinical characteristics of the affected individuals are indistinguishable from those seen in sporadic multiple sclerosis with respect to sex ratio, age at onset, onset symptom, MRI and clinical course. Eleven of 14 cases (78.6%...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awf158

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Role:
Author
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Journal:
Brain : a journal of neurology
Volume:
125
Issue:
Pt 7
Pages:
1474-1482
Publication date:
2002-07-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:ccd6c839-1dc8-4c35-b5a3-af0979a10562
Source identifiers:
32131
Local pid:
pubs:32131

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