We report a family with 15 individuals affected with multiple sclerosis present in three and possibly four generations. The segregation of multiple sclerosis within this pedigree is consistent with an autosomal dominant mode of inheritance with reduced penetrance. The clinical characteristics of the affected individuals are indistinguishable from those seen in sporadic multiple sclerosis with respect to sex ratio, age at onset, onset symptom, MRI and clinical course. Eleven of 14 cases (78.6%...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
A multigenerational family with multiple sclerosis.
If you are the owner of this record, you can report an update to it here: Report update to this record